Hope can fade when multiple medications fail, making each day feel heavier than the last. “What is the success rate of Spravato treatment?” is a question many of our clients ask when they learn about this FDA-approved esketamine nasal spray for treatment-resistant depression.
At Right Track Medical Group, our experts review the evidence with you so you can decide whether to take this innovative next step. Understanding success rates helps set realistic expectations and reduces fear of the unknown. When data replaces doubt, you gain the confidence to explore a promising option.
Unlike traditional antidepressants that primarily target serotonin or norepinephrine, Spravato modulates the N-methyl-D-aspartate (NMDA) receptor, increasing glutamate activity and fostering new neural connections. Spravato is effective because it offers rapid symptom relief to many who have not responded to at least two prior medications. By enhancing your synaptic plasticity, esketamine may restore your brain’s ability to adapt to stressors more effectively.
Spravato is administered under medical supervision twice a week for four weeks. Each session includes taking pre-dose vitals and then spending two hours in observation after your dose to ensure your safety. You will be required to arrange transportation home because transient dissociation can impair driving.
Pivotal Phase III trials reported that about 70 percent of participants achieved a 50 percent reduction in depression symptoms after four weeks when Spravato therapy was combined with an oral antidepressant. About half reached remission by week eight, maintaining improvements through long-term follow-ups with weekly to monthly maintenance doses. These numbers exceed placebo outcomes and represent a meaningful step forward for treatment-resistant cases.
Importantly, trial participants had unsatisfactory results with an average of six prior medications, highlighting Spravato’s potential for successful outcomes even after extensive treatment history. Quality of life scores also improved, reflecting gains in energy, motivation, and social engagement.
Observational studies from outpatient centers mirror trial data, with 60 to 75 percent of patients experiencing significant improvement within two treatment cycles. Patients who paired Spravato with ongoing psychotherapy and maintained consistent sleep schedules reported the highest satisfaction scores. Factors that predict higher success rates with Spravato treatment include:
Clinicians also note that patients who track moods daily using mobile apps tend to recognize early gains and stay motivated, further boosting success rates.
Most side effects, such as dissociation, dizziness, or nausea, are transient and resolve within one to two hours after the dose, allowing most patients to resume normal activities the next morning. Continuous monitoring by trained clinicians ensures safety, and blood pressure is measured multiple times during each visit. Fewer than 5 percent of individuals discontinue treatment due to adverse events.
Because Spravato nasal spray is administered at our office, the risk of misuse is minimal, and federal Risk Evaluation and Mitigation Strategy protocols add an extra layer of oversight. Ongoing research is examining long-term cognitive impacts, but current results show no significant decline in memory or executive function.
The success rate of Spravato treatment redefines what “possible” looks like. Research suggests that a majority of individuals battling treatment-resistant depression experience meaningful improvement with Spravato.
Reach out to Right Track Medical Group to see whether this breakthrough therapy fits in your journey toward renewed hope. A brief phone screening determines eligibility, and your first appointment can often be booked within two weeks.
Imagine waking up to lighter mornings and rediscovering joy in everyday moments. Your path to relief may be just one nasal spray away.
Right Track Medical Group is a physician-led specialty healthcare organization. Our mission is to provide quality, outpatient mental health services for patients in the Southeast.
Learn more about Right Track Medical Group’s approach to quality mental healthcare.
Join our newsletter to receive updates. We respect your privacy and do not share our mailing list.
Right Track Medical Group inspires hope and enhances the emotional well-being of all those we serve by providing accessible, innovative and physician-led mental healthcare services for children, adolescents and adults. Commercial insurance & private pay options available.
We are in-network with most commercial insurance, such as Blue Cross Blue Shield, Cigna, Aetna, United Healthcare, Medicare, Tricare and many more. Please contact your insurance provider to confirm that we are an in-network service for your plan if you are unsure.
Request Appointment Online Request Medication Refill